|
KMID : 0370220130570020095
|
|
Yakhak Hoeji
2013 Volume.57 No. 2 p.95 ~ p.100
|
|
|
Antimicrobial Activities of LCB01-0183, a New Oxazolidinone
|
|
Lee Hyun-Hee
Jung Sung-Ji
Jeong Ji-Woong
Cho Young-Rag
Kim Yong-Zu
Kwak Jin-Hwan
|
|
|
Abstract
|
|
|
|
This study was performed to analyze in vitro and in vivo activities of LCB01-0183, a new oxazolidinone, against clinical isolates of bacteria. In vitro antibacterial activity of LCB01-0183 was tested by the two fold agar dilution method. In vivo activity of LCB01-0183 was determined against systemic infections in mice. LCB01-0183 showed most potent activity among the test compounds against clinical isolates of Gram-positive bacteria. Furthermore, the protective activity of LCB01-0183 was very effective against systemic infections in mice by oral or subcutaneous administration. In time kill study, LCB01-0183 showed a bacteriostatic activity during 24 hours. LCB01-0183 had potent in vitro and in vivo activity against Gram-positive bacteria including drug-resistant strains.
|
|
|
KEYWORD
|
|
|
LCB01-0183, antibacterial activity, MIC, time-kill, oxazolidinone
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|